A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease.
Identifieur interne : 001180 ( Main/Exploration ); précédent : 001179; suivant : 001181A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease.
Auteurs : Hélène Pouclet [France] ; Thibaud Lebouvier ; Emmanuel Coron ; Stanislas Bruley Des Varannes ; Tiphaine Rouaud ; Monica Roy ; Michel Neunlist ; Pascal DerkinderenSource :
- Neurobiology of disease [ 1095-953X ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- pathology : Colon, Enteric Nervous System, Lewy Bodies, Neurons, Parkinson Disease, Rectum.
- Adult, Aged, Biopsy, Cell Count, Female, Humans, Male, Middle Aged.
Abstract
We have shown that routine biopsies of the ascending colon obtained at colonoscopy allow the detection of Lewy neurites (LN) in the enteric nervous system (ENS) of Parkinson's disease (PD) patients. Although colonoscopy is a relatively safe procedure, it requires colon preparation and anesthesia. The present study was therefore undertaken to evaluate whether descending colon and rectal biopsies that are obtainable by rectosigmoidoscopy allow the detection of Lewy pathology in the ENS. A total of 9 controls and 26 PD patients were included and analyzed. Two biopsies were taken from the ascending, descending colon and rectum during the course of a total colonoscopy. Immunohistochemical analysis was performed using antibodies against phosphorylated alpha-synuclein to detect LN and neurofilaments 200 kDa to label the neuronal structures. Biopsies from ascending, descending colon and rectum were morphologically comparable. LN were detected in the biopsies of ascending colon in 17 PD patients (65%), of descending colon in 11 patients (42%) and of rectum in only 6 patients (23%). No LN were seen in control biopsies. Our results show that Lewy pathology follows a rostrocaudal distribution in the colon and rectum of PD patients. Therefore, rectal biopsies have substantially lower sensitivity than ascending colon biopsies to detect Lewy pathology in the gut.
DOI: 10.1016/j.nbd.2011.08.014
PubMed: 21878391
Affiliations:
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Pouclet</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U913, Nantes, F-44093, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U913, Nantes, F-44093</wicri:regionArea><placeName><region type="region" nuts="2">Pays de la Loire</region></placeName></affiliation></author><author><name sortKey="Lebouvier, Thibaud" sort="Lebouvier, Thibaud" uniqKey="Lebouvier T" first="Thibaud" last="Lebouvier">Thibaud Lebouvier</name></author><author><name sortKey="Coron, Emmanuel" sort="Coron, Emmanuel" uniqKey="Coron E" first="Emmanuel" last="Coron">Emmanuel Coron</name></author><author><name sortKey="Des Varannes, Stanislas Bruley" sort="Des Varannes, Stanislas Bruley" uniqKey="Des Varannes S" first="Stanislas Bruley" last="Des Varannes">Stanislas Bruley Des Varannes</name></author><author><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name></author><author><name sortKey="Roy, Monica" sort="Roy, Monica" uniqKey="Roy M" first="Monica" last="Roy">Monica Roy</name></author><author><name sortKey="Neunlist, Michel" sort="Neunlist, Michel" uniqKey="Neunlist M" first="Michel" last="Neunlist">Michel Neunlist</name></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name></author></analytic><series><title level="j">Neurobiology of disease</title><idno type="eISSN">1095-953X</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy</term><term>Cell Count</term><term>Colon (pathology)</term><term>Enteric Nervous System (pathology)</term><term>Female</term><term>Humans</term><term>Lewy Bodies (pathology)</term><term>Male</term><term>Middle Aged</term><term>Neurons (pathology)</term><term>Parkinson Disease (pathology)</term><term>Rectum (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colon</term><term>Enteric Nervous System</term><term>Lewy Bodies</term><term>Neurons</term><term>Parkinson Disease</term><term>Rectum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy</term><term>Cell Count</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have shown that routine biopsies of the ascending colon obtained at colonoscopy allow the detection of Lewy neurites (LN) in the enteric nervous system (ENS) of Parkinson's disease (PD) patients. Although colonoscopy is a relatively safe procedure, it requires colon preparation and anesthesia. The present study was therefore undertaken to evaluate whether descending colon and rectal biopsies that are obtainable by rectosigmoidoscopy allow the detection of Lewy pathology in the ENS. A total of 9 controls and 26 PD patients were included and analyzed. Two biopsies were taken from the ascending, descending colon and rectum during the course of a total colonoscopy. Immunohistochemical analysis was performed using antibodies against phosphorylated alpha-synuclein to detect LN and neurofilaments 200 kDa to label the neuronal structures. Biopsies from ascending, descending colon and rectum were morphologically comparable. LN were detected in the biopsies of ascending colon in 17 PD patients (65%), of descending colon in 11 patients (42%) and of rectum in only 6 patients (23%). No LN were seen in control biopsies. Our results show that Lewy pathology follows a rostrocaudal distribution in the colon and rectum of PD patients. Therefore, rectal biopsies have substantially lower sensitivity than ascending colon biopsies to detect Lewy pathology in the gut.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region></list><tree><noCountry><name sortKey="Coron, Emmanuel" sort="Coron, Emmanuel" uniqKey="Coron E" first="Emmanuel" last="Coron">Emmanuel Coron</name><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name><name sortKey="Des Varannes, Stanislas Bruley" sort="Des Varannes, Stanislas Bruley" uniqKey="Des Varannes S" first="Stanislas Bruley" last="Des Varannes">Stanislas Bruley Des Varannes</name><name sortKey="Lebouvier, Thibaud" sort="Lebouvier, Thibaud" uniqKey="Lebouvier T" first="Thibaud" last="Lebouvier">Thibaud Lebouvier</name><name sortKey="Neunlist, Michel" sort="Neunlist, Michel" uniqKey="Neunlist M" first="Michel" last="Neunlist">Michel Neunlist</name><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name><name sortKey="Roy, Monica" sort="Roy, Monica" uniqKey="Roy M" first="Monica" last="Roy">Monica Roy</name></noCountry><country name="France"><region name="Pays de la Loire"><name sortKey="Pouclet, Helene" sort="Pouclet, Helene" uniqKey="Pouclet H" first="Hélène" last="Pouclet">Hélène Pouclet</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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